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ماکروفاژ موضعی
Other studies have delivered macrophage-polarizing cytokines to di- rectly modulate the phenotype of local macrophages.
, Local macrophage proliferation, rather than recruitment from the blood, is a signa- ture of TH2 inflammation, Science 332 (6035) (2011) 1284-1288.
As wounds heal, the local macrophage population transitions from predominantly pro-inflammatory (M1-like phenotypes) to anti-inflammatory (M2-like phenotypes).
Thus, local macrophages retain pro-inflammatory characteristics.
For example, the type of lipids produced by sebocytes can impact whether local macrophages take on pro- or anti-inflammatory characteristics, which could potentially impede or promote healing in that area (Lovaszi et al.
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